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J Psychiatr Res. 2010 Nov;44(15):1101-5. doi: 10.1016/j.jpsychires.2010.04.006. Epub 2010 May 20.

A family history study of intermittent explosive disorder.

Author information

  • Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA. ecoccaro@yoda.bsd.uchicago.edu.

Abstract

BACKGROUND:

Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial.

METHODS:

Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria.

RESULTS:

Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands.

CONCLUSIONS:

IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
20488459
[PubMed - indexed for MEDLINE]
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