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J Am Chem Soc. 2010 Jun 16;132(23):7870-1. doi: 10.1021/ja103472a.

Synthesis and preliminary biological studies of 3-substituted indoles accessed by a palladium-catalyzed enantioselective alkene difunctionalization reaction.

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  • 1Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.

Abstract

A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.

PMID:
20486685
[PubMed - indexed for MEDLINE]
PMCID:
PMC2896870
Free PMC Article
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