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Pediatr Blood Cancer. 2010 Jul 15;55(1):165-70. doi: 10.1002/pbc.22513.

Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings.

Author information

  • 1Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. kiri.ness@stjude.org

Abstract

PURPOSE:

Analysis of biological samples in large cohort studies may provide insight into the mechanism of, and risk factors for, disease onset and progression.

METHODS:

This study describes the methods used to collect biological samples from a large multi-center cohort of childhood cancer survivors and siblings of childhood cancer survivors and evaluates the predictors of a positive response among these individuals.

RESULTS:

Among survivors, female sex, white race/ethnicity, college graduation, never smoking, accessing the healthcare system in the past 2 years, and having a second malignant neoplasm were the strongest predictors of returning a sample. Among siblings, a similar demographic profile defined those likely to submit the requested sample.

CONCLUSION:

To reduce selection bias and increase the value of these samples for future analysis, additional phone calls and reminders targeting non-responders are needed to improve response rates among those least likely to respond to a single mailed request.

PMID:
20486182
[PubMed - indexed for MEDLINE]
PMCID:
PMC2909600
Free PMC Article

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