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J Biomech. 2010 Aug 10;43(11):2159-63. doi: 10.1016/j.jbiomech.2010.03.048. Epub 2010 May 18.

Simulation of pulmonary air flow with a subject-specific boundary condition.

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  • 1Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, Iowa, USA.


We present a novel image-based technique to estimate a subject-specific boundary condition (BC) for computational fluid dynamics (CFD) simulation of pulmonary air flow. The information of regional ventilation for an individual is derived by registering two computed tomography (CT) lung datasets and then passed to the CT-resolved airways as the flow BC. The CFD simulations show that the proposed method predicts lobar volume changes consistent with direct image-measured metrics, whereas the other two traditional BCs (uniform velocity or uniform pressure) yield lobar volume changes and regional pressure differences inconsistent with observed physiology.

Copyright 2010 Elsevier Ltd. All rights reserved.

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