Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Phys Rev Lett. 2010 Apr 23;104(16):168701. Epub 2010 Apr 19.

Microdynamics and criticality of adaptive regulatory networks.

Author information

  • 1Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, Mount Sinai School of Medicine, New York, New York 10029, USA. ben.macarthur@mssm.edu

Abstract

We present a model of adaptive regulatory networks consisting of a simple biologically motivated rewiring procedure coupled to an elementary stability criterion. The resulting networks exhibit a characteristic stationary heavy-tailed degree distribution, show complex structural microdynamics, and self-organize to a dynamically critical state. We show analytically that the observed criticality results from the formation and breaking of transient feedback loops during the adaptive process.

PMID:
20482087
[PubMed - indexed for MEDLINE]
PMCID:
PMC2925242
Free PMC Article

Images from this publication.See all images (4)Free text

FIG. 1
FIG. 2
FIG. 3
FIG. 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Physical Society Icon for PubMed Central
    Loading ...
    Write to the Help Desk