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Org Lett. 2010 Jun 18;12(12):2841-3. doi: 10.1021/ol100954x.

A simple and efficient approach to the synthesis of 2-phenylquinazolines via sp(3) C-H functionalization.

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  • 1Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, Pr China.


A facile and novel approach to the synthesis of 2-phenylquinazolines was developed via a tandem reaction following sp(3) C-H functionalization. Twenty-five examples of 2-phenylquinazolines were obtained from easily available 2-aminobenzophenones and benzylic amines with good to excellent yields.

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