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Org Lett. 2010 Jun 18;12(12):2822-5. doi: 10.1021/ol100914b.

Stereochemical and skeletal diversity arising from amino propargylic alcohols.

Author information

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Abstract

An efficient synthetic pathway to the possible stereoisomers of skeletally diverse heterocyclic small molecules is presented. The change in shape brought about by different intramolecular cyclizations of diastereoisomeric amino propargylic alcohols is quantified using principal moment-of-inertia (PMI) shape analysis.

PMID:
20481457
[PubMed - indexed for MEDLINE]
PMCID:
PMC2883853
Free PMC Article

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