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Med Oncol. 2011 Dec;28(4):1469-74. doi: 10.1007/s12032-010-9563-7. Epub 2010 May 18.

MicroRNA-21 is involved in osteosarcoma cell invasion and migration.

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  • 1Department of Orthopedics, Union Hospital, and Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1277, 430022, Wuhan, China.

Abstract

MicroRNAs are involved in different cancer-related processes. MicroRNA-21 (miR-21), as an oncomiR, is overexpressed in all kinds of tumors and the role of miR-21 in carcinogenesis is elucidated in many cancers gradually. However, the function of miR-21 in osteosarcoma is still unclear. In our study, we found that miR-21 was significantly overexpressed in osteosarcoma tissues. More importantly, we confirmed that knockdown of miR-21 greatly decreased cell invasion and migration of MG-63. Furthermore, we identified that RECK (reversion-inducing-cysteine-rich protein with kazal motifs), a tumor suppressor gene, was a direct target of miR-21. Finally, the expression of RECK protein negatively correlated with the expression of miR-21 in human osteosarcoma tissues, indicating the potential regulation of RECK by miR-21. Our results suggest that miR-21 expression has a key role in regulating cellular processes in osteosarcoma, likely through regulating RECK and may serve as a therapeutic target.

PMID:
20480266
[PubMed - indexed for MEDLINE]
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