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    Genes Dev. 2010 May 15;24(10):986-91.

    JMJ14, a JmjC domain protein, is required for RNA silencing and cell-to-cell movement of an RNA silencing signal in Arabidopsis.

    Searle IR, Pontes O, Melnyk CW, Smith LM, Baulcombe DC.

    Source

    Plant Sciences Department, Cambridge University, Cambridge, United Kingdom.

    Abstract

    JMJ14 is a histone H3 Lys4 (H3K4) trimethyl demethylase that affects mobile RNA silencing in an Arabidopsis transgene system. It also influences CHH DNA methylation, abundance of endogenous transposon transcripts, and flowering time. JMJ14 acts at a point in RNA silencing pathways that is downstream from RNA-dependent RNA polymerase 2 (RDR2) and Argonaute 4 (AGO4). Our results illustrate a link between RNA silencing and demethylation of histone H3 trimethylysine. We propose that JMJ14 acts downstream from the Argonaute effector complex to demethylate histone H3K4 at the target of RNA silencing.

    PMID:
    20478993
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2867213
    Free PMC Article

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