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Science. 1991 Jun 21;252(5013):1668-75.

Toward a science of metabolic engineering.

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  • 1California Institute of Technology, Pasadena 91125.


Application of recombinant DNA methods to restructure metabolic networks can improve production of metabolite and protein products by altering pathway distributions and rates. Recruitment of heterologous proteins enables extension of existing pathways to obtain new chemical products, alter posttranslational protein processing, and degrade recalcitrant wastes. Although some of the experimental and mathematical tools required for rational metabolic engineering are available, complex cellular responses to genetic perturbations can complicate predictive design.

[PubMed - indexed for MEDLINE]
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