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Cancer Cell. 2010 May 18;17(5):423-5. doi: 10.1016/j.ccr.2010.04.021.

Loss of 53BP1 is a gain for BRCA1 mutant cells.

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  • 1Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.


Mutations in BRCA1 predispose to tumorigenesis presumably from the inability to accurately repair DNA double-strand breaks by homologous recombination. Two new papers shed light on how loss of the DNA damage response protein 53BP1 reverses phenotypes of BRCA1 mutant cells, with potential clinical implications.

(c) 2010 Elsevier Inc. All rights reserved.

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