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J Interferon Cytokine Res. 2010 May;30(5):283-9. doi: 10.1089/jir.2010.0037.

New perspectives in MicroRNA regulation of innate immunity.

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  • 1Centre for Cancer Research, Monash Institute of Medical Research, Monash University , Clayton, Victoria, Australia.


The fine-tuning of the innate immune response by microRNAs (miRNAs) is a concept now supported by a rapidly growing body of evidence. Target prediction analyses indicate that up to a half of innate immune genes could be under the direct regulation of miRNAs. However, the extent to which miRNAs regulate innate immunity remains poorly defined and is currently limited to a handful of target genes. This review highlights several important parameters of miRNA regulation, mostly neglected in the field, which underpin the relevance of miRNAs in the regulation of innate immunity.

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