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Am J Pathol. 2010 Jul;177(1):15-20. doi: 10.2353/ajpath.2010.090955. Epub 2010 May 14.

Selective cell death of hyperploid neurons in Alzheimer's disease.

Author information

  • 1D.Sc., University of Leipzig, Paul Flechsig Institute for Brain Research Jahnallee 59, 04109 Leipzig, Germany. aret@medizin.uni-leipzig.de

Abstract

Aneuploidy, an abnormal number of copies of a genomic region, might be a significant source for neuronal complexity, intercellular diversity, and evolution. Genomic instability associated with aneuploidy, however, can also lead to developmental abnormalities and decreased cellular fitness. Here we show that neurons with a more-than-diploid content of DNA are increased in preclinical stages of Alzheimer's disease (AD) and are selectively affected by cell death during progression of the disease. Present findings show that neuronal hyperploidy in AD is associated with a decreased viability. Hyperploidy of neurons thus represents a direct molecular signature of cells prone to death in AD and indicates that a failure of neuronal differentiation is a critical pathogenetic event in AD.

PMID:
20472889
[PubMed - indexed for MEDLINE]
PMCID:
PMC2893646
Free PMC Article
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