Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mol Cell. 2010 May 14;38(3):323-32. doi: 10.1016/j.molcel.2010.03.013.

Posttranscriptional regulation of microRNA biogenesis in animals.

Author information

  • 1Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. awa403@sc.itc.keio.ac.jp

Abstract

MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes by promoting degradation or repressing translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated, and regulation occurs both transcriptionally and posttranscriptionally. This regulation is crucial, as alteration of miRNA expression has been linked to human diseases, including several cancers. Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals.

Copyright (c) 2010 Elsevier Inc. All rights reserved.

PMID:
20471939
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk