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    J Neuroimmunol. 2010 Aug 25;225(1-2):167-70. Epub 2010 May 15.

    Cytokine mRNA profile of Epstein-Barr virus-stimulated highly differentiated T cells in multiple sclerosis: a pilot study.

    Jaquiéry E, Jilek S, Schluep M, Le Goff G, Garcia M, Pantaleo G, Du Pasquier RA.

    Source

    Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

    Abstract

    The reason why EBV-specific cellular immune responses are abnormal in multiple sclerosis (MS) patients is still missing. In this exploratory pilot study, we assessed IL-1beta, IL-2, IL-4, IL-6, IL-10, IL-17, IFN-gamma, TGF-beta1 and FOXP3 mRNA expression in EBV-stimulated highly differentiated T cells (T(HD)) of MS patients and healthy controls (HC). We found increased levels of IFN-gamma and IL-4 mRNA in CD8+ T(HD) cells of MS patients. All the other tested molecules were expressed similarly in MS patients and HC. Interestingly, increased IFN-gamma and IL-4 suggest that the control of EBV replication may be insufficient in MS patients.

    Copyright 2010 Elsevier B.V. All rights reserved.

    PMID:
    20471696
    [PubMed - indexed for MEDLINE]

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