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Vaccine. 2010 Jul 5;28(30):4798-801. doi: 10.1016/j.vaccine.2010.04.096. Epub 2010 May 14.

Long-term clinical observation of the immunogenicity of inactivated hepatitis A vaccine in children.

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  • 1Ningbo Municipal Center for Disease Control and Prevention, 237 Yongfeng Road, Ningbo, Zhejiang 315010, China.


110 children who were given the complete course of the inactivated hepatitis A vaccine (Havrix) were followed up 10 years later. Age-matched healthy children who were not inoculated served as controls. One month after two primary injections, all children were positive for serum antibody. After 10 years, 99.09% of inoculated children remained positive for serum anti-HAV antibody, with a geometric mean concentration (GMC) of 61.59mIU/mL. GMC values following a secondary immunization in children with antibody levels <20mIU/mL were significantly elevated (567.9mIU/mL), compared with the primary injection alone. Havrix appears to induce persistent immunity and potent immune memory.

Copyright 2010 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
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