Psychiatry Res. 2010 Jul 30;178(2):225-9. Epub 2010 May 14.

Schizophrenia and language--shall we look for a deficit of deviance detection?

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CerCo, Université Toulouse 3, CNRS, Faculté de Médecine de Rangueil, 31062 Toulouse CEDEX9, France. kuzma@cerco.ups-tlse.fr

Abstract

In this article, we consider the view on schizophrenia that asserts this disease originates from a deficit in the hemispheric specialization for language. We suggest that a deficit in the hemispheric specialization for language may be a consequence of the other recently shown neurophysiological deficit of schizophrenia, namely deviance detection. We hypothesise that a deficit of deviance detection related to the dysfunction of NMDA receptors in schizophrenia leads to the abnormal interaction between the parallel and sequential streams of speech processing in the brain. This hypothesis opens perspectives for genetic, molecular and pharmacological studies of the deficit of deviance detection in schizophrenia, as reflected by event-related potentials and neuroimaging during speech processing.

Comment in

Psychiatry Res. 2011 Jul 30;188(2):299; author reply 300-1.

PMID:: 20471102; [PubMed - indexed for MEDLINE]

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Receptors, N-Methyl-D-Aspartate

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Schizophrenia and language--shall we look for a deficit of deviance detection?
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