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Pancreas. 2010 Oct;39(7):989-93. doi: 10.1097/MPA.0b013e3181d91936.

Impact of S-1 on the survival of patients with advanced pancreatic cancer.

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  • 1Department of Gastroenterology, University of Tokyo, Bunkyo-ku, Tokyo, Japan.



The aim of this study was to investigate the effect of S-1 on the prognosis of advanced pancreatic cancer.


In total, 112 patients with pancreatic cancer who received chemotherapy between April 2001 and April 2007 were divided into 2 groups: PreS-1 (53 patients who started chemotherapy before January 2005) and PostS-1 (59 patients who started chemotherapy after February 2005, the time of S-1 introduction). Patient characteristics and clinical outcomes were compared, and prognostic factors were analyzed.


Patient characteristics did not significantly differ between the 2 groups. S-1 was administered as a second-line monotherapy in 5.7% of the PreS-1 group and combined with gemcitabine as a first-line therapy in 27.1% or as second-line monotherapy in 23.7% in the PostS-1 group. Both progression-free survival and overall survival improved after introduction of S-1 (median progression-free survival, 4.4 and 5.3 months; P = 0.043; median overall survival, 9.5 and 13.1 months; P = 0.048 in PreS-1 and PostS-1 groups, respectively). Multivariate analysis revealed that the PostS-1 group (hazards ratio, 0.52; P = 0.003), performance status, and carcinoembryonic antigen were significant prognostic factors for survival.


Introduction of S-1 may improve the prognosis of Japanese patients with advanced pancreatic cancer.

[PubMed - indexed for MEDLINE]
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