Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
AIDS. 2010 Jun 19;24(10):1527-35. doi: 10.1097/QAD.0b013e32833a3946.

Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals.

Collaborators (130)

deWolf F, Bezemer DO, Gras L, Kesselring AM, van Sighem AI, Smit C, Zhang S, Zaheri S, Prin JM, Bos JC, Eeftinck-Schattenkerk JK, Geerlings SE, Godfried MH, Lange JM, van der Meer JT, Nellen FJ, van der Poll T, Reiss P, Sankatsing SU, van der Valk M, Vermeulen JN, Vrouenraets SM, van Vugt M, Wit FW, Schreij G, van der Geest S, Oude Lashof A, Lowe S, Verbon A, Bravenboer B, Pronk MJ, Kuijpers TW, Pajkrt D, Scherpbier HJ, van der Ende ME, Bax H, van der Feltz M, Gelinck LB, Nouwen JL, Rijnders BJ, de Ruiter ED, Slobbe L, Schurink CA, de Vries-Sluijs TE, Driessen G, Hartwig NG, Branger J, Hoogewerf MH, Kauffmann RH, Schippers EF, Groeneveld PH, Alleman MA, Klinieken I, ten Kate RW, Soetekouw R, Kroon FP, Arend SM, de Boer MG, van den Broek PJ, van Dissel JT, van Nieuwkoop C, den Hollander JG, Bronsveld W, Pogany K, Vriesendorp R, Leyten EM, van Houte D, Polée MB, van Vonderen MG, ten Napel CH, Kootstra GJ, Brinkman K, van den Berk GE, Blok WL, Frissen PH, Schouten WE, van Eeden A, Verhagen DW, Mulder JW, van Gorp EC, Wagenaar J, Juttmann JR, van Kasteren ME, Veenstra J, Lettinga KD, Koopmans PP, Brouwer AM, Dofferhoff AS, van der Flier M, de Groot R, ter Hofstede HJ, Keuter M, van der Ven AJ, Sprenger HG, van Assen S, Stek CJ, Doedens R, Scholvinck EH, Hoepelman IM, Bonten MJ, Ellerbroek PM, Hoornenborg E, Jaspers CA, Maarschalk-Ellerbroek LJ, Mudrikova T, Oosterheert JJ, Peters EJ, Schneider MM, Wassenberg MW, Weijer S, Geelen SP, Wolfs TF, Danner SA, van Agtmael MA, Bierman WF, Claessen FA, Hillebrand ME, de Jong EV, Kortmann W, Perenboom RM, bij de Vaate EA, Richter C, van der Berg J, Gisolf EH, Tanis AA, Duits AJ, Durand A, Muskiet F, Voigt R, Winkel K.

Author information

  • 1Stichting HIV Monitoring, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands. A.I.vanSighem@amc.uva.nl

Abstract

OBJECTIVE:

To compare life expectancies between recently diagnosed HIV-infected patients and age and sex-matched uninfected individuals from the general population.

DESIGN:

: National observational HIV cohort in the Netherlands.

METHODS:

Four thousand, six hundred and twelve patients diagnosed with HIV between 1998 and 2007 and still antiretroviral therapy-naive as of 24 weeks after diagnosis were selected. Progression to death compared to the age and sex-matched general population was studied with a multivariate hazards model in 4174 (90.5%) patients without AIDS events at 24 weeks. Life expectancy and number of life years lost were calculated using the predicted survival distribution.

RESULTS:

During 17 580 person-years of follow-up since 24 weeks after diagnosis [median follow-up 3.3 years, interquartile range (IQR) 1.6-5.8], 118 deaths occurred, yielding a mortality rate of 6.7 [95% confidence interval (CI) 5.5-8.0] per 1000 person-years. Median CD4 cell counts at 24 weeks were 480 cells/microl (IQR 360-650). According to the model, the median number of years lived from age 25 was 52.7 (IQR 44.2-59.3; general population 53.1) for men and 57.8 (49.2-63.7; 58.1) for women without CDC-B event. The number of life years lost varied between 0.4 if diagnosed with HIV at age 25 and 1.4 if diagnosed at age 55; for patients with a CDC-B event this range was 1.8-8.0 years.

CONCLUSION:

The life expectancy of asymptomatic HIV-infected patients who are still treatment-naive and have not experienced a CDC-B or C event at 24 weeks after diagnosis approaches that of non-infected individuals. However, follow-up time is short compared to the expected number of years lived.

PMID:
20467289
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk