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Infect Dis Clin North Am. 2010 Jun;24(2):497-514. doi: 10.1016/j.idc.2010.02.002.

Infections transmitted by transplantation.

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  • 1Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA.


Infections are frequently transmitted through solid-organ and, to a lesser extent, stem cell transplantation. There are 2 major types of donor-derived infections that are transmitted: those that would be expected secondary to donor and recipient screening (ie, transmission of cytomegalovirus, Epstein-Barr virus, or toxoplasmosis from a seropositive donor to a seronegative recipient) and those that are unexpected despite routine donor screening (ie, human immunodeficiency virus and hepatitis C virus transmitted from a seronegative donor). Expected transmissions occur frequently and screening and prophylaxis strategies are applied to at-risk individuals in nearly all transplant centers globally. Several high profile donor-derived infectious disease transmissions have been recognized; these reports have raised awareness of this rare complication of transplantation. Issues related to the epidemiology of, screening for, and management of proven or probable donor-derived infections are reviewed in this article.

Copyright (c) 2010 Elsevier Inc. All rights reserved.

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