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Int J Dermatol. 2010 Feb;49(2):115-25. doi: 10.1111/j.1365-4632.2009.04307.x.

Nickel hypersensitivity: a clinical review and call to action.

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  • 1Department of Dermatology, University of Minnesota, School of Medicine, Minneapolis, MN, USA.


Nickel sensitivity is common and increasing in prevalence. This review discusses nickel sensitivity and its association with body piercing and other environmental factors, occupational relevance, and potential implications for implantable metal medical devices. In addition, current European legislation that limits the release of nickel from jewelry is highlighted and an argument for similar legislation elsewhere is presented.

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