Life Sci. 1991;48(26):2493-8.

Multiple populations of serotonin receptors may modulate the behavioral effects of serotonergic agents.

Source

Department of Medicinal Chemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.

Abstract

In order to establish a functional role for the various populations of serotonin (5-HT) receptors, behavioral studies have been conducted over the past decade with serotonergic agonists and antagonists. And, although there is reason to believe that certain behavioral effects may be mediated via particular populations of 5-HT receptors, evidence now suggests that some serotonin-mediated behaviors may be modulated by the interaction of serotonergic agents at multiple subtypes of 5-HT receptors. The generality of these effects, and the exact mechanism(s) by which they occur, have yet to be elucidated. Nevertheless, over the past year, results from several different laboratories provide a growing recognition of this novel phenomenon.

PMID:: 2046474; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Serotonin receptor and reuptake sites: pharmacologic significance. [J Clin Psychiatry. 1990]
Review Serotonin receptor and reuptake sites: pharmacologic significance.
Gonzalez-Heydrich J, Peroutka SJ. J Clin Psychiatry. 1990 Apr; 51 Suppl:5-12; discussion 13.
Multiple receptors mediate the modulatory effects of serotonergic neurons in a small neural network. [J Exp Biol. 1994]
Multiple receptors mediate the modulatory effects of serotonergic neurons in a small neural network.
Zhang B, Harris-Warrick RM. J Exp Biol. 1994 May; 190:55-77.
Review The clinical utility of pharmacological agents that act at serotonin receptors. [J Neuropsychiatry Clin Neurosc...]
Review The clinical utility of pharmacological agents that act at serotonin receptors.
Peroutka SJ, Sleight AJ, McCarthy BG, Pierce PA, Schmidt AW, Hekmatpanah CR. J Neuropsychiatry Clin Neurosci. 1989 Summer; 1(3):253-62.
Review 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis. [Eur J Pharmacol. 2005]
Review 5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis.
de Boer SF, Koolhaas JM. Eur J Pharmacol. 2005 Dec 5; 526(1-3):125-39. Epub 2005 Nov 28.
Serotonin-dependent maintenance of spatial performance and electroencephalography activation after cholinergic blockade: effects of serotonergic receptor antagonists. [Brain Res. 1999]
Serotonin-dependent maintenance of spatial performance and electroencephalography activation after cholinergic blockade: effects of serotonergic receptor antagonists.
Dringenberg HC, Zalan RM. Brain Res. 1999 Aug 7; 837(1-2):242-53.

See reviews... See all...

Cited by 4 PubMed Central articles

Psychedelics and the human receptorome. [PLoS One. 2010]
Psychedelics and the human receptorome.
Ray TS. PLoS One. 2010 Feb 2; 5(2):e9019. Epub 2010 Feb 2.
Locomotor-activated neurons of the cat. I. Serotonergic innervation and co-localization of 5-HT7, 5-HT2A, and 5-HT1A receptors in the thoraco-lumbar spinal cord. [J Neurophysiol. 2009]
Locomotor-activated neurons of the cat. I. Serotonergic innervation and co-localization of 5-HT7, 5-HT2A, and 5-HT1A receptors in the thoraco-lumbar spinal cord.
Noga BR, Johnson DM, Riesgo MI, Pinzon A. J Neurophysiol. 2009 Sep; 102(3):1560-76. Epub 2009 Jul 1.
Effect of 8-hydroxy-2-(N,N-di-n-propylamino)tetralin and MDMA on the discriminative stimulus effects of the classical hallucinogen DOM in rats. [Pharmacol Biochem Behav. 2009]
Effect of 8-hydroxy-2-(N,N-di-n-propylamino)tetralin and MDMA on the discriminative stimulus effects of the classical hallucinogen DOM in rats.
Khorana N, Young R, Glennon RA. Pharmacol Biochem Behav. 2009 Jan; 91(3):385-92. Epub 2008 Aug 17.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Multiple populations of serotonin receptors may modulate the behavioral effects ...
Multiple populations of serotonin receptors may modulate the behavioral effects of serotonergic agents.
Life Sci. 1991 ;48(26):2493-8.

PubMed
Stroke liaison workers for stroke patients and carers: an individual patient dat...
Stroke liaison workers for stroke patients and carers: an individual patient data meta-analysis.
Cochrane Database Syst Rev. 2010 May 12 ;(5):CD005066.

PubMed
Glatiramer acetate for multiple sclerosis.
Glatiramer acetate for multiple sclerosis.
Cochrane Database Syst Rev. 2010 May 12 ;(5):CD004678.

PubMed
Exercise therapy for schizophrenia.
Exercise therapy for schizophrenia.
Cochrane Database Syst Rev. 2010 May 12 ;(5):CD004412.

PubMed
The prevalence of headache may be related with the latitude: a possible role of ...
The prevalence of headache may be related with the latitude: a possible role of Vitamin D insufficiency?
J Headache Pain. 2010 Aug ;11(4):301-7. Epub 2010 May 13 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: