Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Vaccine Immunol. 2010 Jul;17(7):1055-65. doi: 10.1128/CVI.00131-10. Epub 2010 May 12.

Correlates of protection induced by vaccination.

Author information

  • 1Vaxconsult, 4650 Wismer Road, Doylestown, PA 18902, USA. stanley.plotkin@vaxconsult.com

Abstract

This paper attempts to summarize current knowledge about immune responses to vaccines that correlate with protection. Although the immune system is redundant, almost all current vaccines work through antibodies in serum or on mucosa that block infection or bacteremia/viremia and thus provide a correlate of protection. The functional characteristics of antibodies, as well as quantity, are important. Antibody may be highly correlated with protection or synergistic with other functions. Immune memory is a critical correlate: effector memory for short-incubation diseases and central memory for long-incubation diseases. Cellular immunity acts to kill or suppress intracellular pathogens and may also synergize with antibody. For some vaccines, we have no true correlates, but only useful surrogates, for an unknown protective response.

PMID:
20463105
[PubMed - indexed for MEDLINE]
PMCID:
PMC2897268
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central Icon for Fred Hutchinson Cancer Research Ctr Arnold Library
    Loading ...
    Write to the Help Desk