Format

Send to:

Choose Destination
See comment in PubMed Commons below
Diabetes Care. 2010 Aug;33(8):1789-91. doi: 10.2337/dc09-2276. Epub 2010 May 11.

Long-term pancreas allograft survival in simultaneous pancreas-kidney transplantation by era: UNOS registry analysis.

Author information

  • 1Terasaki Foundation Laboratory, Los Angeles, California, USA. kwaki@terasakilab.org

Abstract

OBJECTIVE:

To determine whether short-term improvement in pancreas graft survival with simultaneous pancreas-kidney (SPK) transplants translated into improved long-term survival, then to examine the implications of that determination.

RESEARCH DESIGN AND METHODS:

We analyzed data for 14,311 diabetic patients who received a first SPK transplant between October 1987 and November 2007, using Kaplan-Meier analysis for graft survival rates and Cox regression analysis for year-of-transplant effect.

RESULTS:

Overall, from 1995 to 2004, 5-year pancreas graft survival stayed about the same (70-71%). Limiting analysis to grafts that survived more than 1 year, 5-year survival from 1987 to 2004 ranged from 80 to 84%. With 1987-1989 as reference, the adjusted hazard ratio for graft failure by year of transplant increased to 1.49 (95% CI 0.97-2.30) in 2000-2004.

CONCLUSIONS:

Long-term pancreas graft survival has remained unchanged despite the dramatic decreases in technical failures and early acute rejection rates that have contributed to prolonged SPK graft survival.

PMID:
20460444
[PubMed - indexed for MEDLINE]
PMCID:
PMC2909063
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk