Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
BMC Musculoskelet Disord. 2010 May 10;11:88. doi: 10.1186/1471-2474-11-88.

Low urine pH and acid excretion do not predict bone fractures or the loss of bone mineral density: a prospective cohort study.

Author information

  • 1Department of Community Health Sciences, Faculty of Medicine, University of Calgary TRW Building, 3rd Floor, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6, Canada. tanisfenton@shaw.ca

Abstract

BACKGROUND:

The acid-ash hypothesis, the alkaline diet, and related products are marketed to the general public. Websites, lay literature, and direct mail marketing encourage people to measure their urine pH to assess their health status and their risk of osteoporosis.The objectives of this study were to determine whether 1) low urine pH, or 2) acid excretion in urine [sulfate + chloride + 1.8x phosphate + organic acids] minus [sodium + potassium + 2x calcium + 2x magnesium mEq] in fasting morning urine predict: a) fragility fractures; and b) five-year change of bone mineral density (BMD) in adults.

METHODS:

DESIGN:

Cohort study: the prospective population-based Canadian Multicentre Osteoporosis Study. Multiple logistic regression was used to examine associations between acid excretion (urine pH and urine acid excretion) in fasting morning with the incidence of fractures (6804 person years). Multiple linear regression was used to examine associations between acid excretion with changes in BMD over 5-years at three sites: lumbar spine, femoral neck, and total hip (n = 651). Potential confounders controlled included: age, gender, family history of osteoporosis, physical activity, smoking, calcium intake, vitamin D status, estrogen status, medications, renal function, urine creatinine, body mass index, and change of body mass index.

RESULTS:

There were no associations between either urine pH or acid excretion and either the incidence of fractures or change of BMD after adjustment for confounders.

CONCLUSION:

Urine pH and urine acid excretion do not predict osteoporosis risk.

PMID:
20459740
[PubMed - indexed for MEDLINE]
PMCID:
PMC2890599
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for BioMed Central Icon for PubMed Central
    Write to the Help Desk