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Phytochemistry. 2010 Jul;71(10):1040-9. doi: 10.1016/j.phytochem.2010.04.016. Epub 2010 May 8.

Multifunctional flavonoid dioxygenases: flavonol and anthocyanin biosynthesis in Arabidopsis thaliana L.

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  • 1Institut für Pharmazeutische Biologie, Philipps Universität Marburg, Deutschhausstr. 17A, D-35037 Marburg/Lahn, Germany.


Flavonols and conditionally also anthocyanins, aside from flavonols, are the predominant polyphenols accumulated in various tissues of the model plant Arabidopsis thaliana L. In vitro experiments suggested that the dioxygenases involved in their biosynthesis, flavonol synthase and anthocyanidin synthase, are "multifunctional" enzymes showing distinct side activities. The in vivo relevance of the additional activities attributed to these enzymes, however, has remained obscure. In this review we summarize the most recent results and present final proof of the complementing activities of these synthases for flavonol and anthocyanidin formation in the model plant A. thaliana. The impact of their modification on the biosynthetic pathway and the pattern of flavonoids in different plant tissues are discussed.

2010 Elsevier Ltd. All rights reserved.

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