(A) Annual hazard rates (incidence rate per year among patients who are still susceptible) for MDS/AML and sepsis death, by years on therapy with G-CSF. Dot-dash curves (green for MDS/AML and yellow for sepsis death) show estimates obtained from prior data; solid curves (blue for MDS/AML and grey for sepsis death) show estimates obtained using updated follow-up. Shaded regions show point-wise 95% confidence envelopes for new estimates; error bars show point-wise 95% confidence intervals for previous estimates at selected years. (B) Corresponding estimates of cumulative incidence (cumulative proportion experiencing each event as initial cause of failure, in patients at risk of each adverse event), by years on G-CSF therapy, using updated follow-up (solid curves and shaded regions), compared with prior data (dot-dash curves and error bars).

All estimates are based on updated follow-up. Error bars show point-wise 95% confidence limits at selected years. (A) Cumulative incidence of MDS/AML (blue curve) and sepsis death (black curve) among patients who achieved an adequate mean ANC count by months 6 - 18 (≥2.188 cells/l) at doses of G-CSF less than or equal to 8 μg/kg/day). (B) Corresponding cumulative incidence curves among patients who failed to achieve an adequate ANC count despite higher doses of G-CSF.