Nat Methods. 2010 Jun;7(6):447-9. doi: 10.1038/nmeth.1455. Epub 2010 May 9.

Coding of facial expressions of pain in the laboratory mouse.

Langford DJ, Bailey AL, Chanda ML, Clarke SE, Drummond TE, Echols S, Glick S, Ingrao J, Klassen-Ross T, Lacroix-Fralish ML, Matsumiya L, Sorge RE, Sotocinal SG, Tabaka JM, Wong D, van den Maagdenberg AM, Ferrari MD, Craig KD, Mogil JS.

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Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada.

Abstract

Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain. This measure of spontaneously emitted pain may provide insight into the subjective pain experience of mice.

Comment in

The author file: Jeffrey Mogil. [Nat Methods. 2010]
The author file: Jeffrey Mogil.Banker M. Nat Methods. 2010 Jun; 7(6):415.
Do mice have a pain face? [Nat Methods. 2010]
Do mice have a pain face?Flecknell PA. Nat Methods. 2010 Jun; 7(6):437-8.

PMID:: 20453868; [PubMed - indexed for MEDLINE]

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Coding of facial expressions of pain in the laboratory mouse.
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Nat Methods. 2010 Jun ;7(6):447-9. doi: 10.1038/nmeth.1455. Epub 2010 May 9 .

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