Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Med Microbiol. 2010 Aug;300(6):357-62. doi: 10.1016/j.ijmm.2010.04.002. Epub 2010 May 10.

Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens.

Author information

  • Laboratory of Bacterial Pathogenesis, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. vaf@rockefeller.edu

Abstract

Endolysins (or lysins) are highly evolved enzymes produced by bacteriophage (phage for short) to digest the bacterial cell wall for phage progeny release. In Gram-positive bacteria, small quantities of purified recombinant lysin added externally results in immediate lysis causing log-fold death of the target bacterium. Lysins have been used successfully in a variety of animal models to control pathogenic antibiotic-resistant bacteria found on mucosal surfaces and infected tissues. Their specificity for the pathogen without disturbing the normal flora, the low chance of bacterial resistance, and their ability to kill colonizing pathogens on mucosal surfaces, a capacity previously unavailable, make them ideal anti-infectives in an age of mounting resistance. Here we review the current literature showing the effectiveness of these enzymes in controlling a variety of infections.

Copyright 2010 Elsevier GmbH. All rights reserved.

PMID:
20452280
[PubMed - indexed for MEDLINE]
PMCID:
PMC3666336
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk