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Fitoterapia. 2010 Oct;81(7):816-9. doi: 10.1016/j.fitote.2010.04.009. Epub 2010 May 5.

Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins.

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  • 1Dipartimento dei Materiali e delle Risorse Naturali, Universit√† di Trieste, Via A. Valerio 6, 34127 Trieste, Italy.


A selection of seven phytocannabinoids representative of the major structural types of classic cannabinoids and their corresponding cannabivarins was investigated for in vivo topical anti-inflammatory activity in the Croton oil mouse ear dermatitis assay. Differences in the terpenoid moiety were far more important for anti-inflammatory activity than those at the C-3 alkyl residue, suggesting the involvement not only of cannabinoid receptors, but also of other inflammatory end-points targeted by phytocannabinoids.

Copyright © 2010 Elsevier B.V. All rights reserved.

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