Format

Send to:

Choose Destination
See comment in PubMed Commons below
Org Biomol Chem. 2010 Apr 21;8(8):1749-62. doi: 10.1039/b923331h.

The use of click chemistry in the emerging field of catalomics.

Author information

  • 1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore117543.

Abstract

Of the thousands of known chemical reactions, a handful of reactions, called "click" reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(i)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments.

PMID:
20449474
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Royal Society of Chemistry
    Loading ...
    Write to the Help Desk