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Org Biomol Chem. 2010 Apr 21;8(8):1749-62. doi: 10.1039/b923331h.

The use of click chemistry in the emerging field of catalomics.

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  • 1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore117543.


Of the thousands of known chemical reactions, a handful of reactions, called "click" reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(i)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments.

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