Abstract
Matrix metalloproteinase inhibitors (MMPi) possessing a glucose protecting group on the zinc-binding group (ZBG) show a dramatic increase in inhibitory activity upon cleavage by beta-glucosidase.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Matrix Metalloproteinase Inhibitors*
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Matrix Metalloproteinases / metabolism*
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Molecular Structure
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Prodrugs / chemistry
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Prodrugs / metabolism
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Prodrugs / pharmacology
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Protease Inhibitors / chemistry*
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Protease Inhibitors / metabolism
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Protease Inhibitors / pharmacology*
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beta-Glucosidase / metabolism*
Substances
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Matrix Metalloproteinase Inhibitors
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Prodrugs
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Protease Inhibitors
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beta-Glucosidase
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Matrix Metalloproteinases