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Neurologist. 2010 May;16(3):199-202. doi: 10.1097/NRL.0b013e3181a3cb53.

Cerebral vasculopathy after 4-bromo-2,5-dimethoxyphenethylamine ingestion.

Author information

  • 1Department of Neurology, University of California,San Francisco, 505 Parnassus Ave., M798, San Francisco, CA 94143, USA. Josiah.ambrose@ucsf.edu

Abstract

BACKGROUND:

4-bromo-2,5-dimethoxyphenethylamine (2C-B) is a designer-drug variant of 3,4-methylenedioxymethamphetamine (ecstasy) whose recreational use has increased significantly over the last 10 years. Neurologic consequences of 2C-B usage are currently unknown.

CASE REPORT:

A 43-year-old woman experienced severe headaches within 48 hours of taking liquid 2C-B, after which time she developed progressive encephalopathy and quadraparesis, which did not improve over several months. MRA and cerebral angiogram imaging demonstrated profound vascular abnormalities of large, medium, and small-caliber vessels with subsequent watershed infarction. Brain biopsy and cerebrospinal fluid studies ruled out an inflammatory process.

CONCLUSIONS:

This case demonstrates an idiosyncratic and devastating neurologic response to 2C-B, a recreational drug whose popularity has increased with widespread availability of online guides for its synthesis.

PMID:
20445431
[PubMed - indexed for MEDLINE]
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