Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Biol Chem. 2010 Jul 9;285(28):21203-7. doi: 10.1074/jbc.R110.119743. Epub 2010 May 5.

Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.

Author information

  • 1Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. jlorsch@jhmi.edu

Abstract

A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.

PMID:
20444698
[PubMed - indexed for MEDLINE]
PMCID:
PMC2898419
Free PMC Article

Images from this publication.See all images (2)Free text

FIGURE 1.
FIGURE 2.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk