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Curr Opin Struct Biol. 2010 Jun;20(3):351-9. doi: 10.1016/ Epub 2010 May 3.

Evolution: a guide to perturb protein function and networks.

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  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.


Protein interactions give rise to networks that control cell fate in health and disease; selective means to probe these interactions are therefore of wide interest. We discuss here Evolutionary Tracing (ET), a comparative method to identify protein functional sites and to guide experiments that selectively block, recode, or mimic their amino acid determinants. These studies suggest, in principle, a scalable approach to perturb individual links in protein networks.

Copyright 2010 Elsevier Ltd. All rights reserved.

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