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Curr Opin Struct Biol. 2010 Jun;20(3):351-9. doi: 10.1016/j.sbi.2010.04.002. Epub 2010 May 3.

Evolution: a guide to perturb protein function and networks.

Author information

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. lichtarge@bcm.edu

Abstract

Protein interactions give rise to networks that control cell fate in health and disease; selective means to probe these interactions are therefore of wide interest. We discuss here Evolutionary Tracing (ET), a comparative method to identify protein functional sites and to guide experiments that selectively block, recode, or mimic their amino acid determinants. These studies suggest, in principle, a scalable approach to perturb individual links in protein networks.

Copyright 2010 Elsevier Ltd. All rights reserved.

PMID:
20444593
[PubMed - indexed for MEDLINE]
PMCID:
PMC2916956
Free PMC Article

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