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J Ethnopharmacol. 2010 Jul 6;130(1):187-90. doi: 10.1016/j.jep.2010.04.035. Epub 2010 May 2.

Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats.

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  • 1Department of Basic Nursing Science, Korea University School of Nursing, Seoul 136-713, South Korea.

Abstract

AIM OF THE STUDY:

The purpose of the present study was to screen aromatic essential oils that have antidepressant effects to identify the regulatory mechanisms of selected essential oils.

MATERIALS AND METHODS:

The antidepressant effects of essential oils of Anthemis nobilis (chamomile), Salvia sclarea (clary sage; clary), Rosmarinus officinalis (rosemary), and Lavandula angustifolia (lavender) were assessed using a forced swim test (FST) in rats. Rats were treated with essential oils by intraperitoneal injection or inhalation. Serum levels of corticosterone were assessed by enzyme-linked immunosorbent assay (ELISA).

RESULTS:

Among the essential oils tested, 5% (v/v) clary oil had the strongest anti-stressor effect in the FST. We further investigated the mechanism of clary oil antidepression by pretreatment with agonists or antagonists to serotonin (5-HT), dopamine (DA), adrenaline, and GABA receptors. The anti-stressor effect of clary oil was significantly blocked by pretreatment with buspirone (a 5-HT(1A) agonist), SCH-23390 (a D(1) receptor antagonist) and haloperidol (a D(2), D(3), and D(4) receptor antagonist).

CONCLUSIONS:

Our findings indicate that clary oil could be developed as a therapeutic agent for patients with depression and that the antidepressant-like effect of clary oil is closely associated with modulation of the DAnergic pathway.

Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

PMID:
20441789
[PubMed - indexed for MEDLINE]
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