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Genome Biol. 2010;11(5):R47. doi: 10.1186/gb-2010-11-5-r47. Epub 2010 May 6.

Computational challenges in the analysis of ancient DNA.

Author information

  • 1Max-Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany. pruefer@eva.mpg.de

Abstract

High-throughput sequencing technologies have opened up a new avenue for studying extinct organisms. Here we identify and quantify biases introduced by particular characteristics of ancient DNA samples. These analyses demonstrate the importance of closely related genomic sequence for correctly identifying and classifying bona fide endogenous DNA fragments. We show that more accurate genome divergence estimates from ancient DNA sequence can be attained using at least two outgroup genomes and appropriate filtering.

PMID:
20441577
[PubMed - indexed for MEDLINE]
PMCID:
PMC2898072
Free PMC Article

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