Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 2010 Jun 15;201(12):1909-18. doi: 10.1086/652748.

Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola.

Author information

  • 1Médecins Sans Frontières-Spain, Barcelona, Spain.

Abstract

BACKGROUND:

Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)-recommended case definitions for MHF.

METHODS:

Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity.

RESULTS:

A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our data-derived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions.

CONCLUSIONS:

Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.

PMID:
20441515
[PubMed - indexed for MEDLINE]
PMCID:
PMC3407405
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk