Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Medicina (Kaunas). 2010;46(2):89-94.

Factors determining age-related macular degeneration: a current view.

[Article in English, Lithuanian]

Author information

  • 1Department of Ophthalmology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania. rliutkeviciene@gmail.com.


Age-related macular degeneration affects the macula and is the leading cause of significant and irreversible central visual loss. It is the most common cause of visual loss in people older than 60 years. The pathogenesis of age-related macular degeneration is complex and not completely understood. It is thought that age-related macular degeneration has a multifactorial etiology, the development of which may be caused by interrelation of environmental and genetic factors and body characteristics. In this article, risk factors such as age, gender, cigarette smoking, color of the iris, nutrition, body mass index, oxidative stress, and genetic factors (complement factor H gene, Apo E gene, and others) are reviewed. Here, choroidal neovascularization process, in which hypoxia, inflammatory process, and proteolytic enzymes play a determinant role, is discussed. Considerable attention is paid to genetic polymorphism of matrix metalloproteinases, especially to matrix metalloproteinases 2 and 9, respectively gelatinases A and B, also to matrix metalloproteinase 9.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lithuanian University of Health Sciences
    Loading ...
    Write to the Help Desk