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Proc Natl Acad Sci U S A. 2010 May 18;107(20):9329-34. doi: 10.1073/pnas.1000324107. Epub 2010 May 3.

Ultraviolet A does not induce melanomas in a Xiphophorus hybrid fish model.

Author information

  • 1Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA. dmitchel@mdanderson.org

Abstract

We examined the wavelength dependence of ultraviolet (UV) ra-diation (UVR)-induced melanoma in a Xiphophorus backcross hybrid model previously reported to be susceptible to melanoma induction by ultraviolet A (UVA) and visible light. Whereas ultraviolet B (UVB) irradiation of neonates yielded high frequencies of melanomas in pigmented fish, UVA irradiation resulted in melanoma frequencies that were not significantly different from unirradiated fish. Spontaneous and UV-induced melanoma frequencies correlated with the degree of pigmentation as expected from previous studies, and the histopathology phenotypes of the melanomas were not found in significantly different proportions in UV-treated and -untreated tumor-bearing fish. Our results support the conclusion that a brief early-life exposure to UVB radiation causes melanoma formation in this animal model. These data are consistent with an essential role for direct DNA damage, including cyclobutane dimers and (6-4) photoproducts, in the etiology of melanoma.

PMID:
20439744
[PubMed - indexed for MEDLINE]
PMCID:
PMC2889042
Free PMC Article

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