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    RNA Biol. 2010 May-Jun;7(3):300-4. Epub 2010 May 21.

    The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer.

    Greene SB, Herschkowitz JI, Rosen JM.

    Source

    Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.

    Abstract

    Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.

    PMID:
    20436283
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3008649
    Free PMC Article

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