Display Settings:

Format

Send to:

Choose Destination
Biochim Biophys Acta. 2011 Mar;1810(3):350-60. doi: 10.1016/j.bbagen.2010.04.006. Epub 2010 May 8.

Nanoscale engineering of extracellular matrix-mimetic bioadhesive surfaces and implants for tissue engineering.

Author information

  • 1Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.

Abstract

BACKGROUND:

The goal of tissue engineering is to restore tissue function using biomimetic scaffolds which direct desired cell fates such as attachment, proliferation and differentiation. Cell behavior in vivo is determined by a complex interaction of cells with extracellular biosignals, many of which exist on a nanoscale. Therefore, recent efforts in tissue engineering biomaterial development have focused on incorporating extracellular matrix- (ECM) derived peptides or proteins into biomaterials in order to mimic natural ECM. Concurrent advances in nanotechnology have also made it possible to manipulate protein and peptide presentation on surfaces on a nanoscale level.

SCOPE OF REVIEW:

This review discusses protein and peptide nanopatterning techniques and examples of how nanoscale engineering of bioadhesive materials may enhance outcomes for regenerative medicine.

MAJOR CONCLUSIONS:

Synergy between ECM-mimetic tissue engineering and nanotechnology fields can be found in three major strategies: (1) Mimicking nanoscale orientation of ECM peptide domains to maintain native bioactivity, (2) Presenting adhesive peptides at unnaturally high densities, and (3) Engineering multivalent ECM-derived peptide constructs.

GENERAL SIGNIFICANCE:

Combining bioadhesion and nanopatterning technologies to allow nanoscale control of adhesive motifs on the cell-material interface may result in exciting advances in tissue engineering. This article is part of a Special Issue entitled Nanotechnologies - Emerging Applications in Biomedicine.

2010 Elsevier B.V. All rights reserved.

PMID:
20435097
[PubMed - indexed for MEDLINE]
PMCID:
PMC2924948
Free PMC Article

Images from this publication.See all images (9)Free text

Fig 2
Fig 3
Fig 4
Fig 5
Fig 6
Fig 7
Fig 8
Fig 9
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk