Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Infect. 2010 Jul;61(2):144-9. doi: 10.1016/j.jinf.2010.04.010. Epub 2010 May 23.

Serial testing of interferon-gamma-release assays for the diagnosis of latent tuberculosis in hemodialysis patients.

Author information

  • 1Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Republic of Korea.

Abstract

INTRODUCTION:

The performance of serial interferon-gamma-release assays (IGRAs) for the diagnosis of latent tuberculosis has not been studied in hemodialysis patients.

METHOD:

The QuantiFERON-TB-Gold In-Tube test (QFT) and T-SPOT-TB test (TSPOT) were performed 1 year after initial testing at a hemodialysis center.

RESULTS:

Ninety-eight patients were included in the final analysis. Positive rates for the initial tuberculin skin test (TST), QFT and TSPOT were 26.5%, 43.9% and 58.2%, respectively. The follow-up QFT and TSPOT showed positive responses in 52.0% and 53.1%. Conversion rates of the QFT and TSPOT were 20.0% and 26.8%. Reversion rates of the QFT and TSPOT were 16.3% and 29.8%; however, they decreased to 0.0% and 4.8% in patients with a concordantly positive response at the initial TST. A group at high risk for latent tuberculosis increased the risk for the TSPOT conversion [odds ratio (95% confidence interval), 7.76 (1.27-47.40)] and showed a trend of increasing the risk for the QFT conversion [1.97 (0.45-8.71)]. Reversion of both the QFT [18.92 (2.01-178.65)] and TSPOT [6.16 (1.57-24.19)] occurred more frequently in the group at low risk.

CONCLUSIONS:

Both conversion and reversion of the IGRAs were associated with the risk for latent tuberculosis in hemodialysis patients. However, serial IGRAs results should be interpreted cautiously due to their high variability.

PMID:
20435059
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk