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Methods. 2010 Nov;52(3):218-22. doi: 10.1016/j.ymeth.2010.04.013. Epub 2010 Apr 29.

DNA methylation profiling using HpaII tiny fragment enrichment by ligation-mediated PCR (HELP).

Author information

  • 1Center for Epigenomics and Division of Computational Genetics, Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA.

Abstract

The HELP assay is a technique that allows genome-wide analysis of cytosine methylation. Here we describe the assay, its relative strengths and weaknesses, and the transition of the assay from a microarray to massively-parallel sequencing-based foundation.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
20434563
[PubMed - indexed for MEDLINE]
PMCID:
PMC2954265
Free PMC Article

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