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J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 1;878(27):2554-62. doi: 10.1016/j.jchromb.2010.03.015. Epub 2010 Apr 3.

Measurement of pyrethroid, organophosphorus, and carbamate insecticides in human plasma using isotope dilution gas chromatography-high resolution mass spectrometry.

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  • 1National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy., NE, Mailstop F-17, Atlanta, GA 30341, USA.

Abstract

We have developed a gas chromatography-high resolution mass spectrometry method for measuring pyrethroid, organophosphorus, carbamate and fipronil pesticides and the synergist piperonyl butoxide in human plasma. Plasma samples were extracted using solid phase extraction and were then concentrated for injection and analysis using isotope dilution gas chromatography-high resolution mass spectrometry. The limits of detection ranged from 10 to 158 pg/mL with relative recoveries at concentrations near the LODs (e.g., 25 or 250 pg/mL) ranging from 87% to 156% (9 of the 16 compounds were within ±15% of 100%). The extraction recoveries ranged from 20% to 98% and the overall method relative standard deviations were typically less than 20% with some exceptions. Analytical characteristics were determined at 25, 250, and 1000 pg/mL.

Copyright © 2010 Elsevier B.V. All rights reserved.

PMID:
20434413
[PubMed - indexed for MEDLINE]
PMCID:
PMC3024141
Free PMC Article
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