Biochimie. 2011 Jan;93(1):39-45. Epub 2010 Apr 28.

Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation.

Laugerette F, Vors C, Peretti N, Michalski MC.

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Universite de Lyon, F-69100 Villeurbanne, France.

Abstract

Metabolic diseases such as obesity are characterized by a subclinical inflammatory state that contributes to the development of insulin resistance and atherosclerosis. Recent reports also indicate that (i) there are alterations of the intestinal microbiota in metabolic diseases and (ii) absorption of endogenous endotoxins (namely lipopolysaccharides, LPS) can occur, particularly during the digestion of lipids. The aim of the present review is to highlight recently gained knowledge regarding the links between high fat diets, lipid digestion, intestinal microbiota and metabolic endotoxemia & inflammation.

PMID:: 20433893; [PubMed - indexed for MEDLINE]

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