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J Cell Physiol. 2010 Aug;224(2):289-99. doi: 10.1002/jcp.22150.

Histone chaperones, histone acetylation, and the fluidity of the chromogenome.

Author information

  • 1Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA. jeffrey.c.hansen@colostate.edu

Abstract

The "chromogenome" is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post-translational acetylation of histones, and modulation of the chromogenome. We emphasize those chaperones that function in a replication-independent manner, and for which three-dimensional structural information has been obtained. The emerging links between histone acetylation and chaperone function in both yeast and higher metazoans are discussed, including the importance of nucleosome-free regions. We close by posing many questions pertaining to how the coupled action of histone chaperones and acetylation influences chromogenome structure and function.

PMID:
20432449
[PubMed - indexed for MEDLINE]
PMCID:
PMC3184832
Free PMC Article

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