Stroke. 2010 Jun;41(6):1185-92. Epub 2010 Apr 29.
Endovascular thrombectomy for acute ischemic stroke in failed intravenous tissue plasminogen activator versus non-intravenous tissue plasminogen activator patients: revascularization and outcomes stratified by the site of arterial occlusions.
Smith WS, Sung G, Hormel P, Malisch TW, Giannotta SL, Rudolph S, Charbel FT, Kim P, Budzik R, Gobin YP, Grobelny T, Higashida RT, Kidwell C, Lutsep HL, Marks M, Nesbit G, Rymer MM, Saver J, Silverman EI, Smith WS, Starkman S, Sung G, Starkman S, Duckwiler G, Leary M, Kidwell C, Saver J, Vinuela F, Jahan R, Gobin YP, Guzy J, Barnwell S, Wayne C, Lowenkopf T, North E, Quinn J, Egan R, Kuether T, Roll J, Luh G, Nesbit G, Dugan B, Grobelny T, Akhtar N, Arkin S, Bettinger I, Rymer M, Weinstein C, Schwartzman M, Boutwell C, Gruenenfelder B, Koroshetz W, Pryor J, Badjatia N, Buonarmo F, Conrad L, Greer D, Nogueira R, Rabinov J, Guy R, Rosand J, Schwamm L, Sims J, Smith E, Hoh B, Hirsch J, Ayata C, Hochberg L, Cacciola J, Pile-Spellman J, Lavine S, Mangla S, Meyers P, Schmidt L, Silverman I, Ohki S, Speigel G, Ahlquist M, Beland D, Segal A, Liu AH, Ougrets I, Riina H, Gobin YP, Salvaggio K, Higashida R, Dowd C, Halbach V, Singh V, Ko N, Elkins J, Johnston SC, Hemphill JC, Bonovich DC, Filler S, Huang-Hellinger F, Mitchell S, Budzik R, Eubank G, Arce E, Fulop J, Lippert J, Davis T, McGraw JK, Pema P, Meyers P, Marks M, Do H, Albers G, Hsia A, Tong D, Wijamn C, Marcellus M, Bernard J, DeFilipp G, Bellon R, McGinnis B, Dietrich A, Putnam S, Boltes P, Watson V, DeSimone J, Yepes M, Kowal T, Stallmeyer J, Obuchowski A, Zoarski G, LaMonte M, Wozniack M, Schofield D, Liebeskind D, Kasner S, Cucchiara B, Messe S, Taylor R, McGarvey M, Hurst R, Bagley L, Weigele J, Clarke J, Koroshetz W, Frerichs K, Feske S, Norbash A, Hendersen G, Sorond F, Baker J, Chen P, O'Hara J, Jacobs J, Yananse L, Blatter D, Lee Bahr A, Harker C, Pisani D, Walker K, Schonoholz C, D'Agostino H, Nanda A, Kelley R, Singleton D, Hopkins LN, Guterman L, Levy E, Howington J, Harrigan M, Hanel R, Crumlish A, Solander S, Felix A, Sen S, Huang D, Melendez N, Wilson S, Katz P, Glenn B, Koci T, Bruno A, Algood M, Heffner M, Barr J, Broadbent P, Singer SA, Morris SD, Dixit S, Miller G, Frey J, McDougall C, Albuquerque F, Hekler M, Fiorella D, Larson S, Ladha S, Okuda D, Harrigan M, Rouge B, Alexander A, Acosta J, Olson J, Callerame K, Hillis R, Hendricks K, Tong F, Dion J, Frankel M, Stern B, Samuels O, Chimowitz M, Campbell M, Choi J, Yatsu F, Malkoff M, Grotta J, Cacayorin E, Hall C, Labiche L, Noser E, Song J, Uchino K, Smith D, Amar A, Kim P, Budzik R, Duckwiler G, Frei D, Gobin YP, Grobelny T, Higashida RT, Hellinger F, Huddle D, Kidwell C, Koroshetz W, Liebeskind DS, Lutsep HL, Marks M, Nesbit G, Rymer MM, Saver J, Silverman IE, Smith WS, Starkman S, Sung G, Akhtar N, Grobelny T, Allen A, Arkin S, Bettinger I, Boutwell C, Grau C, Gruenenfelder-felder B, Rymer M, Schwartzman M, Weinstein C, Budzik R, Arce E, Berarducci A, Davis T, Dean M, Dolen E, Eubank G, Jim F, Gao-Hickman X, Lippert J, William M, McGraw JK, Meyers P, Pema P, Wyatt R, Lutsep H, Barnwell S, Clark W, Dugan B, Egan R, Kuether T, Lowenkopf T, Nesbit G, North E, Peterson B, Roll J, Yanase L, Silverman I, Ahlquist M, Dawn B, Gomes J, Ohki S, Speigel G, Starkman S, Ali L, Buck B, Chute D, Duckwiler G, Guzy J, Jahan R, Kim D, Liebeskind DS, Marder V, Ovbiagele B, Rajajee V, Restrepo L, Sanossian N, Saver J, Selco S, Shah S, Shukman M, Tateshima S, Towfighi A, Vespa P, Villablanca JP, Vinters H, Vinuela F, Frei D, Huddle D, Bellon R, Finale C, Greenwald C, Smith D, Hellinger F, Billanovic L, Mitchell S, Segal A, Gobin P, Katz J, Ougrets I, Riina H, Salvaggio K, Hill M, Barker P, Demchuk A, Dzialowski I, Fischer K, Hu W, Hudon M, Morrish W, Subramanian S, Watson T, Wong J, Pile-Spellman J, Lavine S, Meyers P, Schmidt L, Watson V, DeSimone J, Hodics T, Kowal T, Parham F, Sutten S, Yepes M, Marks M, Albers G, Castle J, Do H, Jayerman M, Lansberg M, Marcellus M, Venkatsubmaran C, Wijman C, Shuaib A, Ashforth R, Emery D, Al-Hussain F, Hussain M, Jeerakathil T, Khan K, Murtaoghu M, Nazir N, Saqqur M, Scozzafava J, Scwindt B, Siddiqui M, Tariq K, Barr J, Broadbent P, Dixit S, Miller G, Morris SD, Jovin T, Hammer M, Horowitz M, Reddy V, Santucci T, Uchino K, Vora N, Wechsler L.
Source
Division of Interventional Neuroradiology, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Los Angeles, CA 90095-7437, USA.
Abstract
BACKGROUND AND PURPOSE:
Intracranial mechanical thrombectomy is a therapeutic option for acute ischemic stroke patients failing intravenous tissue plasminogen activator (IV tPA). We compared patients treated by mechanical embolus removal in cerebral ischemia (MERCI) thrombectomy after failed IV tPA with those treated with thrombectomy alone.
METHODS:
We pooled MERCI and Multi MERCI study patients, grouped them either as failed IV tPA or non-IV tPA, and assessed revascularization rates, procedural complications, symptomatic hemorrhage rates, clinical outcomes, and mortality. We also evaluated outcomes stratified by the occlusion site and final revascularization.
RESULTS:
Among 305 patients, 48 failed, and 257 were ineligible for IV tPA. Nonresponders to IV tPA trended toward a higher revascularization rate (73% versus 63%) and less mortality (27.7% versus 40.1%) and had similar rates of symptomatic hemorrhage and procedural complications. Favorable 90-day outcomes were similar in failed and non-IV tPA patients (38% versus 31%), with no difference according to occlusion site. Among patients failing IV tPA, good outcomes tended to occur more frequently in revascularized patients (47.1% versus 15.4%), although this relationship was attributable solely to middle cerebral artery and not internal carotid artery occlusions, with no difference in mortality. Among IV tPA-ineligible patients, revascularization correlated with good outcome (47.4% versus 4.4%) and less mortality (28.5% versus 59.6%).
CONCLUSIONS:
The risks of hemorrhage and procedure-related complications after mechanical thrombectomy do not differ with respect to previous IV tPA administration. Thrombectomy after IV tPA achieves similar rates of good outcomes, a tendency toward lower mortality, and similar revascularization rates when stratified by clot location. Good outcomes correlate with successful revascularization except with internal carotid artery occlusions in tPA-nonresponders.
- PMID:
- 20431084
- [PubMed - indexed for MEDLINE]
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