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Curr Opin Microbiol. 2010 Jun;13(3):344-9. doi: 10.1016/j.mib.2010.03.003. Epub 2010 Apr 27.

The biomass objective function.

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  • 1GT Life Sciences, Inc., 10520 Wateridge Circle, San Diego, CA 92122, USA.

Abstract

Flux balance analysis (FBA) is a mathematical approach for analyzing the flow of metabolites through a metabolic network. To computationally predict cell growth using FBA, one has to determine the biomass objective function that describes the rate at which all of the biomass precursors are made in the correct proportions. Here we review fundamental issues associated with its formulation and use to compute optimal growth states.

Copyright 2010 Elsevier Ltd. All rights reserved.

PMID:
20430689
[PubMed - indexed for MEDLINE]
PMCID:
PMC2912156
Free PMC Article

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