Send to

Choose Destination
See comment in PubMed Commons below
Semin Cutan Med Surg. 2010 Mar;29(1):3-9. doi: 10.1016/j.sder.2010.03.001.

New insights in the immunologic basis of psoriasis.

Author information

  • 1Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065, USA.


Psoriasis vulgaris is a multifactorial heritable disease characterized by severe inflammation resulting in poorly differentiated, hyperproliferative keratinocytes. Recent advances in genetic analyses have implicated components regulating the interleukin (IL)-23 and nuclear factor-kappaB pathways as risk factors for psoriasis. These inflammatory pathways exhibit increased activity in skin lesions, and promote secretion of various cytokines, such as IL-17 and IL-22. Unrestrained, the activated inflammatory cytokine network in psoriasis may trigger a vicious cycle of inflammation and cellular proliferation that ultimately results in lesion formation. These advances in genetic analyses, together with the progress made in targeted biological therapy, pave the path to tailor treatment on the basis of an individual's genetic and immunologic profile.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontline Medical Communications Inc Icon for PubMed Central
    Loading ...
    Write to the Help Desk